diff --git a/src/ffi/platforms/arm64.cc b/src/ffi/platforms/arm64.cc
index df215ecafed3..8ff0f1c959d1 100644
--- a/src/ffi/platforms/arm64.cc
+++ b/src/ffi/platforms/arm64.cc
@@ -243,6 +243,11 @@ extern "C" bool node_ffi_create_fast_trampoline(
     if (IsFloatType(args[i])) {
       fp_count++;
     } else {
+      // The buffer helper call clobbers target registers already loaded for
+      // earlier arguments, so only a leading buffer argument is supported.
+      if (IsPointerValueType(args[i]) && gp_count != 0) {
+        return false;
+      }
       gp_count++;
       has_buffer_args = has_buffer_args || IsPointerValueType(args[i]);
     }
diff --git a/src/ffi/platforms/x64.cc b/src/ffi/platforms/x64.cc
index d5c15c381574..0167bc7b5aac 100644
--- a/src/ffi/platforms/x64.cc
+++ b/src/ffi/platforms/x64.cc
@@ -367,6 +367,11 @@ extern "C" bool node_ffi_create_fast_trampoline(
     if (IsFloatType(args[i])) {
       fp_count++;
     } else {
+      // The buffer helper call clobbers target registers already loaded for
+      // earlier arguments, so only a leading buffer argument is supported.
+      if (IsPointerValueType(args[i]) && gp_count != 0) {
+        return false;
+      }
       gp_count++;
       has_buffer_args = has_buffer_args || IsPointerValueType(args[i]);
     }